(PECAM1) (c-term) Rabbit PaB

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Product name

M CD31 (Pecam1), polyclonal antibody

Full Product Name

CD31 M antibody (C term)

Product synonym names

Platelet endothelial cell adhesion molecule; PECAM-1; CD31; Pecam1; Pecam; Pecam-1

Product gene name

anti-Pecam1 antibody

Antibody / peptide pairs

The CD31 peptide (MBS9217985) is used to block the activity of the M antibody CD31 (MBS9213675)

Immunogen sequence positions: 508-536

3D structure: ModBase 3D Structure for Q08481

Clonality: Polyclonal

Isotype: Rabbit Ig

Host: Rabbit

Species reactivity: Mouse, hamster

Specificity

This mouse CD31 antibody is generated from rabbits immunized with a synthetic peptide conjugated to KLH between 508-536 amino acids from the C-terminal region of mouse CD31.

Purity / Purification

Peptide affinity purified rabbit polyclonal antibody (Pab)

Shape / Format

Purified polyclonal antibody supplied in PBS with 0.09% (w / v) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Cell Location

Cellular membrane; Single-pass type I membrane protein. Cellular membrane; Lipid anchor. Note on cell attachment = It is located in the lateral border recycling compartment (LBRC) and is recycled from the LBRC to attachment in resting endothelial cells.

Tissue location

Isoform 1 and isoform 3 are expressed in lungs and platelets.

Preparation and storage

Keep refrigerated at 2-8 degrees C for up to 2 weeks. For long-term storage, store at -20 degrees C in small aliquots to avoid freeze-thaw cycles.

Other notes

Occasionally, small volumes of anti-Pecam1 antibody vial (s) may become trapped in the product vial seal during shipping and storage. If necessary, briefly centrifuge the vial in a benchtop centrifuge to dislodge any liquid on the lid of the container. Some products may need to be shipped with dry ice and an additional fee may apply for dry ice.

Related Product Information for anti-Pecam1 antibody

Cell adhesion molecule that is required for transendothelial leukocyte migration (TEM) in most inflammatory conditions. Tyr-679 plays a critical role in TEM and is necessary for efficient traffic of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to target migrating leukocytes. It prevents ingestion of phagocytes from closely opposite viable cells by transmitting ‘shedding’ signals, and changes function in apoptosis, promoting the binding of dying cells to phagocytes (the meeting of a viable cell with a phagocyte through The homophilic interaction of PECAM1 on both cell surfaces leads to active repulsion of the viable phagocyte cell. During apoptosis, the inside-out signaling of PECAM1 is somehow deactivated so that the apoptotic cell no longer actively rejects the phagocyte The lack of this repulsion signal together with the interaction of the Eat-me signals and their respective receptors causes the apoptotic cell to bind to the phagocyte, thus triggering the engulfing process). Modulates BDKRB2 activation (by similarity). Induce susceptibility to atherosclerosis.

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