Specification

Host Species: Mouse

Antibody Isotype: IgG1

Clone: PG-3

Species Reactivity: N / A

Immunogen: N Epsilon (Carboxymethyl) Lysine (CML) -HSA

Conjugated: Unconjugated

Objective

Alternative names: CML; N Epsilon (carboxymethyl) lysine

Product Background

Summary of the gene

BCR (Breakpoint Cluster Region) is a protein-coding gene. Diseases associated with BCR include leukemia, chronic myeloid, somatic and leukemia, acute lymphoblastic. Related pathways include GPCR signaling and Rho GTPase signaling. GO annotations related to this gene include protein tyrosine kinase activity and enzyme binding. An important parameter of this gene is ABR. A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is within the BCR gene. The translocation produces a fusion protein that is encoded by the sequence of BCR and ABL, the gene at the breakpoint of chromosome 9. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase activating protein for p21rac. Two transcriptional variants have been found that encode different isoforms for this gene.

Antigen Description

Chronic myeloid leukemia (CML) [MIM: 608232]: A clonal myeloproliferative disorder of a pluripotent stem cell with a specific cytogenetic abnormality, the Philadelphia chromosome (Ph), involving myeloid, erythroid, megakaryocytic, B lymphoid cells, and, a sometimes T lymphoid but not medullary fibroblasts. Note = The gene represented in this entry is involved in the pathogenesis of the disease. Note = A chromosomal aberration involving BCR has been found in patients with chronic myeloid leukemia. Translocation t (9; 22) (q34; q11) with ABL1. The translocation produces a BCR-ABL that is also found in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). The breakpoint cluster region (BCR) protein also known as NY-REN-26 renal carcinoma antigen is a protein that is encoded in humans by the BCR gene. BCR is one of the two genes in the BCR-ABL complex, which is associated with the Philadelphia chromosome. Two transcriptional variants have been found that encode different isoforms for this gene. Although the BCR-ABL fusion protein has been studied extensively, the function of the normal BCR gene product is unclear. The protein has serine/threonine kinase activity and is a GTPase activating protein for RAC1 and CDC42. N epsilon carboxymethyl lysine (CML or carboxymethyl lysine) is formed by the non-enzymatic reaction of glucose with Schiff’s base proteins, followed by an Amadori rearrangement and oxidation leaving only one carboxymethyl group attached to lysine. Th.